Effect of multispecies Probiotic Supplementation on irritable Bowel Syndrome

Background:  Irritable  bowel  syndrome  (IBS)  is  a  common,  chronic  and  sometimes  disabling functional disorder of the gastrointestinal  system and its treatment remains as health problem. Thus the aim of this study was to evaluate  the Effect  of multispecies  probiotic  supplementation,  as a novel and Controversial therapeutic method on Irritable bowel syndrome.

Materials  and Methods:  In  this  randomized  double  blind  Placebo-controlled clinical  trial,  60 patients with IBS were enrolled.  The patients were divided randomly  into two groups. Patients  in intervention  group  received  two  500  mg  probiotic  capsules  (Familact®)  and  in  control  group, received two 500 mg placebo capsules daily for 30 consecutive days. The symptoms and quality of life were measured and compared at the beginning and just after the end of study for each case.

Results: Results  showed  the mean  score  of Abdominal  pain  after  1 month  of treatment  in the probiotic group was significantly lower than the control group (1.76 ± 2.04 vs. 2.88 ± 2.25, P=0.049,respectively). While, other symptoms and quality of life did not change significantly (P>0.05). Furthermore,  defecation  habit and global symptoms  improvement  was similar after intervention  in both groups and we did not observe significant differences in these items (P>0.05).